Monocyte Distribution Width: Sepsis Biomarker in Emergency Department

Monocyte Distribution Width (MDW): Novel Sepsis Biomarker in the Emergency Department

New analysis from the pivotal study confirms abnormal MDW at presentation increases the odds of sepsis. Used early in emergency department patients, MDW enhances the odds of early sepsis detection by ~6-fold utilizing Sepsis-2 and ~4-fold based on Sepsis-3 criteria.

Diagnostic uncertainty is a major challenge for patients presenting to the emergency department with a low number of signs and symptoms.

New analysis of a pivotal study of 2,158 patients at three leading academic centers sought to determine if monocyte distribution width (MDW), a new sepsis biomarker, can aid in early sepsis detection in adult patients with present or developing sepsis symptoms in the emergency department.

The value of MDW is that it provides physicians with an earlier indication of sepsis during the initial encounter, which is especially important when a patient’s symptoms are mild and alternative diagnoses are being considered.

Elliott Crouser

M.D., professor of Critical Care Medicine

Ohio State University Wexler Medical Center

The study determined that, when considered along with the standard physiologic parameters at the time of patient presentation, abnormal values of MDW signify a 4-6x increase in probability of sepsis diagnosis. In patients with a low level of symptoms and highest diagnostic uncertainty at presentation, abnormal MDW increased the odds of sepsis by ~3x.¹

Early sepsis in the emergency department

Peer-Reviewed Clinical Study MDW Improves SIRS and qSOFA Early Sepsis Detection in the Emergency Department

New analysis from a pivotal study shows that patients with abnormal MDW values at presentation have increased odds of sepsis.

Read study

Referenced in This Article

Early Sepsis Detection

^1. Crouser, E. D., Parrillo, J. E., Martin, G. S., Huang, D. T., Hausfater, P., Grigorov, I., Tejidor, L. (2020). Monocyte distribution width enhances early sepsis detection in the emergency department beyond SIRS and qSOFA. Journal of Intensive Care, 8(1). doi:10.1186/s40560-020-00446-3

Information addressed to health professionals. The products presented on this site are for professional use only, and, where applicable, comply with the requirements of the IVD Directive 98/79 / EC. Instructions for use must be consulted before using these products.

© 2022 Beckman Coulter, Inc. All rights reserved. Beckman Coulter, the stylized logo, and the Beckman Coulter product and service marks mentioned herein are trademarks or registered trademarks of Beckman Coulter, Inc. in the United States and other countries. All other trademarks are the property of their respective owners.

U.S. Government Users Restricted Rights - As per GSA ADP Schedule Contract with Beckman Coulter, Inc., the use, duplication or disclosure is restricted as follows: Beckman Coulter hereby authorizes user to copy those documents published on the World Wide Web by Beckman Coulter, for noncommercial use, and only within the user's organization. Except as expressly provided above, nothing contained herein shall be construed as granting any license or right under any Beckman Coulter copyright. Nothing contained herein shall be construed as granting by implication, estoppel or otherwise any license or right under any patent or trademark of Beckman Coulter or any third party.

Choose your country/region and language

Country or Region

Language

Monocyte Distribution Width (MDW): Novel Sepsis Biomarker in the Emergency Department

Monocyte Distribution Width (MDW): Novel Sepsis Biomarker in the Emergency Department

Peer-Reviewed Clinical Study MDW Improves SIRS and qSOFA Early Sepsis Detection in the Emergency Department

Referenced in This Article